Biomedicines | Free Full-Text | Glycine Transporter 1 Inhibitors: Predictions on Their Possible Mechanisms in the Development of Opioid Analgesic Tolerance
In this review, we shed light on undiscovered targets in opioid analgesic tolerance, namely glycine transporter type 1 (GlyT1). The prediction is supported by the following evidence from the literature: (i) GlyT1 regulates extrasynaptic glycine concentrations; (ii) glycine acts as a co-agonist at GluN2A-2DRs; (iii) GluN2B is predominantly found in the extrasynaptic region; and (iv) GluN2BR plays a crucial role in the development of opioid analgesic tolerance.
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