JAL | Free Full-Text | Skeletal Muscle Transcriptome Alterations Related to Declining Physical Function in Older Mice
4.2. Regressions of DEGs with CFAB
There are far more DEGs at the older age (6m–28m) that might have a role in functional loss or are potentially involved in the regulation of muscle mass. More than 10-fold DEGs were identified to be strongly associated with function in the 6m–28m group (372) than the 6m–24m (35). Furthermore, different DEGs were among the top |R| values in the two groups, and there were different |R| values for the same DEGs in the two analyses, potentially indicating that some genes can play a more significant role in the decline of physical function depending upon the age of the mouse.
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