JPM | Free Full-Text | Analysis of the Technical Accuracy of a Patient-Specific Stereotaxy Platform for Brain Biopsy

13
JPM | Free Full-Text | Analysis of the Technical Accuracy of a Patient-Specific Stereotaxy Platform for Brain Biopsy


Author Contributions

Conceptualization, M.M.; methodology, M.M., R.M. and R.G.; software, M.M., R.M. and M.W.; validation, M.M. and M.W.; formal analysis, M.M., M.W. and R.G.; investigation, M.M.; resources, M.M, E.G., W.-G.D. and D.W.; data curation, M.M.; writing—original draft preparation, M.M.; writing—review and editing, M.M., R.M. and M.W.; visualization, M.M. and M.W.; supervision, E.G., D.W., W.-G.D. and R.G.; project administration, M.M., D.W. and R.G.; funding acquisition, M.M., D.W. and R.G. All authors have read and agreed to the published version of the manuscript.

Figure 1.
Process sequence of the applied method for accuracy analysis.

Figure 1.
Process sequence of the applied method for accuracy analysis.

Jpm 14 00180 g001

Figure 2.
Eleven positions of the bone anchors and MRI markers on the skull.

Figure 2.
Eleven positions of the bone anchors and MRI markers on the skull.

Jpm 14 00180 g002

Figure 3.
Location of target points in the cerebral brain in frontal view (left) and sagittal view (right). The coordinate origin and the positive axis direction are marked with an arrow.

Figure 3.
Location of target points in the cerebral brain in frontal view (left) and sagittal view (right). The coordinate origin and the positive axis direction are marked with an arrow.

Jpm 14 00180 g003

Figure 4.
Constructed and placed biopsy frame on the skull with two target trajectories.

Figure 4.
Constructed and placed biopsy frame on the skull with two target trajectories.

Jpm 14 00180 g004

Figure 5.
Alignment of the frames in the 3D printing build room.

Figure 5.
Alignment of the frames in the 3D printing build room.

Jpm 14 00180 g005

Figure 6.
Measurement setup for accuracy evaluation of patient-specific frames with GOM ATOS Core 300 scanner.

Figure 6.
Measurement setup for accuracy evaluation of patient-specific frames with GOM ATOS Core 300 scanner.

Jpm 14 00180 g006

Figure 7.
Measuring point definition for the measuring system suitability.

Figure 7.
Measuring point definition for the measuring system suitability.

Jpm 14 00180 g007

Figure 8.
A schematic representation for determining the target point deviation. Left green needle point represents the planned target point and the right red needle point represents the measured actual target point. From the space coordinates, the distances d x y , d z and d r e s determined.

Figure 8.
A schematic representation for determining the target point deviation. Left green needle point represents the planned target point and the right red needle point represents the measured actual target point. From the space coordinates, the distances d x y , d z and d r e s determined.

Jpm 14 00180 g008

Figure 9.
Restrictions for deformation analysis using the example of the small frame. With “A” as fixed support and “B–G” as remote displacement.

Figure 9.
Restrictions for deformation analysis using the example of the small frame. With “A” as fixed support and “B–G” as remote displacement.

Jpm 14 00180 g009

Figure 10.
Measuring system suitability; object and user influence.

Figure 10.
Measuring system suitability; object and user influence.

Jpm 14 00180 g010

Figure 11.
Target point deviation in the XY-plane, Z-direction and results in the comparisons CAD vs. print (A), print vs. sterile (B) and CAD vs. sterile (C). ** high significantly (p < 0.01).

Figure 11.
Target point deviation in the XY-plane, Z-direction and results in the comparisons CAD vs. print (A), print vs. sterile (B) and CAD vs. sterile (C). ** high significantly (p < 0.01).

Jpm 14 00180 g011

Figure 12.
Correlation between frame size and target point deviation in CAD vs. sterile comparison as mean value right and left target point.

Figure 12.
Correlation between frame size and target point deviation in CAD vs. sterile comparison as mean value right and left target point.

Jpm 14 00180 g012

Figure 13.
Influence of distance A and B of the target point deviation of stereotaxic frames after sterilization (CAD vs. sterile).

Figure 13.
Influence of distance A and B of the target point deviation of stereotaxic frames after sterilization (CAD vs. sterile).

Jpm 14 00180 g013

Figure 14.
Deformation result from the simulation with 40 times magnification on the example of the smallest frame No. 6.

Figure 14.
Deformation result from the simulation with 40 times magnification on the example of the smallest frame No. 6.

Jpm 14 00180 g014

Figure 15.
Target point deviation of the largest and smallest stereotaxis frame after RPS alignment and numerical simulation (FEM).

Figure 15.
Target point deviation of the largest and smallest stereotaxis frame after RPS alignment and numerical simulation (FEM).

Jpm 14 00180 g015

Table 1.
Technical parameters for MRI imaging.

Table 1.
Technical parameters for MRI imaging.

Parameter 3-Tesla MRT
Sequence T1W
Cutting plane sagittal
Coil head
Field of View 260 mm
Repetition time 9.3
Echo time 4.3
Matrix 640
Slice thickness 1 mm
Pixel size 0.4 mm × 0.4 mm

Table 2.
Length designation for measuring system suitability.

Table 2.
Length designation for measuring system suitability.

L1 NRD Needle guide point right distal NLD Needle guide point left distal
L2 NRP Needle guide point right proximal NLP Needle guide point left proximal
L3 F1D Fixing point 1 distal F2D Fixing point 2 distal
L4 F1P Fixing point 1 proximal F2P Fixing point 2 proximal
L5 F1D Fixing point 1 distal F3D Fixing point 3 distal
L6 F1P Fixing point 1 proximal F3P Fixing point 3 proximal
L7 F2D Fixing point 2 distal F3D Fixing point 3 distal
L8 F2P Fixing point 2 proximal F3P Fixing point 3 proximal
L9 F1D Fixing point 1 distal NRD Needle guide point right distal
L10 F1D Fixing point 1 distal NLD Needle guide point left distal
L11 F1P Fixing point 1 proximal NLP Needle guide point left proximal
L12 F1P Fixing point 1 proximal NRP Needle guide point right proximal

Table 3.
Values of the target point deviation in the XY-plane, Z-direction and results in the comparisons CAD vs. print, print vs. sterile and CAD vs. sterile.

Table 3.
Values of the target point deviation in the XY-plane, Z-direction and results in the comparisons CAD vs. print, print vs. sterile and CAD vs. sterile.

CAD vs. Print Print vs. Sterile CAD vs. Sterile
Mean STD Mean STD Mean STD
XY-plane 0.46 0.24 0.16 0.05 0.44 0.18
Z-direction 0.17 0.16 0.06 0.04 0.17 0.11
results 0.51 0.23 0.18 0.05 0.50 0.20

Table 4.
Values of the target point deviation of the largest and smallest stereotaxis frame after RPS alignment and numerical simulation (FEM).

Table 4.
Values of the target point deviation of the largest and smallest stereotaxis frame after RPS alignment and numerical simulation (FEM).

RPS FEM Difference
Small Large Small Large Small Large
XY-plane 0.71 0.40 0.60 0.41 −0.11 0.01
Z-direction 0.05 0.24 0.60 0.02 0.56 −0.22
results 0.71 0.41 0.86 0.41 0.15 −0.01

Disasters Expo USA, is proud to be supported by Inergency for their next upcoming edition on March 6th & 7th 2024!

The leading event mitigating the world’s most costly disasters is returning to the Miami Beach

Convention Center and we want you to join us at the industry’s central platform for emergency management professionals.
Disasters Expo USA is proud to provide a central platform for the industry to connect and
engage with the industry’s leading professionals to better prepare, protect, prevent, respond
and recover from the disasters of today.
Hosting a dedicated platform for the convergence of disaster risk reduction, the keynote line up for Disasters Expo USA 2024 will provide an insight into successful case studies and
programs to accurately prepare for disasters. Featuring sessions from the likes of The Federal Emergency Management Agency,
NASA, The National Aeronautics and Space Administration, NOAA, The National Oceanic and Atmospheric Administration, TSA and several more this event is certainly providing you with the knowledge
required to prepare, respond and recover to disasters.
With over 50 hours worth of unmissable content, exciting new features such as their Disaster
Resilience Roundtable, Emergency Response Live, an Immersive Hurricane Simulation and
much more over just two days, you are guaranteed to gain an all-encompassing insight into
the industry to tackle the challenges of disasters.
By uniting global disaster risk management experts, well experienced emergency
responders and the leading innovators from the world, the event is the hub of the solutions
that provide attendees with tools that they can use to protect the communities and mitigate
the damage from disasters.
Tickets for the event are $119, but we have been given the promo code: HUGI100 that will
enable you to attend the event for FREE!

So don’t miss out and register today: https://shorturl.at/aikrW

And in case you missed it, here is our ultimate road trip playlist is the perfect mix of podcasts, and hidden gems that will keep you energized for the entire journey

-

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More