Chronic

Differential gene expression associated with GABA and glutamate neurotransmission systems in the cortex and hippocampus. Clustergram heat map of mRNA expression of…

1. IntroductionChronic illnesses are pervasive and persistent on a global scale, thus posing significant challenges to public health and, significantly, contributing to over 70% of global mortality . Chronic illnesses encompass a…

1. IntroductionHepatitis B virus (HBV) infection is a serious global health problem, and chronic HBV infection significantly increases the risk of liver fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC) in patients . The…

Dr. Chelisa Cardinez (pictured) says the discovery finally provides an explanation for why patients with psoriasis may go on to develop psoriatic arthritis, leaving…

Credit: Unsplash/CC0 Public Domain Australians experiencing chronic knee pain achieve similar pain reduction whether they consult with…

Chronic pain leads to accelerated brain aging. Credit: Xie Rui In a study published in Nature Mental Health, scientists from China and the…

Alexandre Boulanger is better know for building self-balancing exoskeletons at Wandercraft. For his next trick the Paris-based robotics entrepreneur is fronting work on a far lighter kind of wearable: An arm-worn patch for…

In the summer of 2005, Qasim Amin Nathari was giving the sermon for Jumuah (Friday prayers in the Muslim religion) to about 200 members of a New Jersey congregation. He wasn't nervous. He had no reason to be. He knew these people and…

1. IntroductionChronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease, affecting 1.9–4% of the European population . Cases of CRSwNP in Europe are mostly dominated by type 2 inflammatory patterns characterized by…

1. IntroductionHypertension and chronic kidney disease (CKD) are pathophysiological states that are intimately related, as hypertension can be both a cause and a consequence of CKD. The prevalence of hypertension is high among patients…

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Soisungwan SatarugSoisungwan Satarug Prof. Soisungwan Satarug is an academic researcher from the Translational…

You likely know from experience that sleep and mood go hand in hand. A sleepless night can leave you feeling crabby the next morning and put a damper on your whole day. When you have chronic insomnia, night after night of lying in bed…

1. IntroductionChronic rhinosinusitis (CRS) is a significant healthcare burden and a major public health concern . Chronic rhinosinusitis is the term used for rhinosinusitis that lasts for more than 12 weeks. It is characterised by two…

1. IntroductionAccess to healthcare is widely recognized as a fundamental and basic human right. However, individuals with chronic health conditions often face challenges in accessing healthcare services. Individuals with rare diseases…

Viral infections can cause malignant diseases by utilizing elements of the viral genome, modulating normal cell cycle and repair mechanisms, constantly keeping the cells in an activated state, and disrupting the normal cell cycle…

Abstract Although a comprehensive history and physical exam are the mainstays of initial evaluation, plain X-rays are clinically indicated for chronic knee pain of greater than 6 weeks duration and acute…

Behavioral Sciences, Vol. 14, Pages 220: The Influence of Emotional Intelligence on Quality of Life in Patients Undergoing Chronic Hemodialysis Focused on Age and Gender Behavioral Sciences doi: 10.3390/bs14030220 Authors: Afra…

1. IntroductionIschemic cardiovascular disease (CVD) remains a leading cause of morbidity and mortality both in the United States and worldwide. Beyond its effects on individual patients, this disease entity also imposes a substantial…

IJERPH, Vol. 21, Pages 302: Chronic Stress Indicator: A Novel Tool for Comprehensive Stress Analysis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph21030302 Authors: Matthew Hill Sayed Mostafa…

Elevated markers of DNA damage in striatal neurons associated with OUD and chronic morphine in rhesus macaque. Credit: Nature Communications (2024). DOI:…

1. IntroductionSince the start of the COVID-19 pandemic caused by the SARS-CoV-2 virus in 2020, there have been over 760 million cases and 6.8 million deaths reported as of March 2023 . SARS-CoV-2 utilizes the angiotensin-converting…

1 Introduction With the rapid aging of society, the number of people with dementia is likely to increase. Dementia in aging populations is one of the largest health and economic issues globally. Japan is projected to have the world’s…

1. IntroductionChronic Obstructive Pulmonary Disease (COPD) is a persistent health condition characterized by airflow limitations, making it the sixth leading cause of death in the United States (US) . The burden of COPD is expected to…

1. IntroductionThe ankle joint is the farthest joint from the center of the human body and bears the highest weight-bearing burden. In addition, because it is a joint that directly contacts the ground while walking, it is responsible…

1. IntroductionChronic obstructive pulmonary disease (COPD) is a highly prevalent and progressive respiratory disease, resulting in substantial morbidity and mortality . The worldwide prevalence of COPD is approximately 10.3%, but this…

Credit: CC0 Public Domain When you're an autistic teenager living with chronic pain, getting treatment for your pain can be a challenging…

1. IntroductionLow back pain is one of the most prevalent and expensive musculoskeletal disorders worldwide . Particularly, non-specific low back pain is defined as low back pain (LBP) that cannot be associated with an identifiable…

1. IntroductionThe aging rate in South Korea ranks first among the countries of the Organization for Economic Co-operation and Development (OECD). By 2026, it is expected that approximately 20% of the population will be 65 years or…

1. IntroductionIn the last few years, high-income countries reported end-stage kidney disease (ESKD) prevalence around 800–2400 per million population . A 2016 meta-analysis of the prevalence of chronic kidney disease (CKD) in the world…

1. IntroductionChronic hepatitis B (CHB) is a significant global health concern, with over 290 million carriers worldwide, leading to more than 820,000 deaths annually and exceeding US$2 billion in associated costs . In Taiwan, where…

Healthcare, Vol. 12, Pages 479: Associations between COVID-19 Pandemic-Related Overtime, Perceived Chronic Stress and Burnout Symptoms in German General Practitioners and Practice Personnel—A Prospective Study Healthcare doi:…

1. IntroductionEquity in cancer prevention is a critical public health priority. In general, common cancers (e.g., colorectal) and cancers with increasing incidence rates (e.g., thyroid) have established, targetable risk factors,…

1. IntroductionPatients seeking medical guidance most frequently mention pain as a major symptom, which is one of the leading causes of disability globally . Pain is described as ‘an unpleasant sensory and emotional experience…

Pain that lasts more than a few months is chronic pain. Some types can’t be cured. But treatment can help you find relief.The right choice for you depends on:How long the pain has lastedHow bad it isWhat's causing itWhere you…

Chronic obstructive pulmonary disease affects the lungsSEBASTIAN KAULITZKI/SCIENCE PHOTO LIBRARY Delivering medication to the lungs with inhalable nanoparticles may help treat chronic obstructive pulmonary disease…

1 Introduction Anhedonia is defined as the diminished capacity to experience pleasure. The concept was rarely used before the 1980s and was officialized in the DSM-III, becoming a necessary symptom for depression diagnosis (Der-Avakian…

TMEM97 gene is expressed in human DRG. Credit: Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.2306090120 A new…

1. IntroductionOpioid analgesics (OAs), a highly effective pain-relieving medication group, are available as one possible option for the treatment of severe chronic non-tumor pain (CNTP) . The German evidence-based guideline provides…

In this study, we investigated the applicability of HBcrAg for monitoring during and after antiviral treatment in patients with chronic hepatitis B and chronic HBV infection. We demonstrated that during treatment with NA, both levels of…

1. IntroductionSystemic inflammation without evident clinical infection is common in CKD patients . This can exacerbate various pre-existing comorbidities such as cardiovascular disease, malnutrition and erythropoietin-resistant anemia,…

2.1. Chronic Impairment of the Immune System in CKDIndividuals with CKD are at an increased risk of death from non-cardiovascular causes, mainly by infection . Of note, kidneys can be among the target organs during infections by…

By Eddy BallChronic kidney disease of unknown origin (CKDu) has become a widespread threat to health among the agricultural populations of developing countries in South Asia and along the Pacific Coast of Central America, most…

In the published article, there was an error in the Acknowledgments, which listed an incorrect project number (“NBU-FFR-2023-0177”). The correct Acknowledgments appear below. Acknowledgments The authors extend their appreciation to the…

West Virginia coal mine meets POV screening criteria; receives postponement noticeWASHINGTON – The U.S. Department of Labor’s Mine Safety and Health Administration today released the results of its second 2023 pattern of violations…

By Adeline Lopez The workshop was an international collaborative effort between NIEHS, NIDDK, IRET, PAHO, SEARO, and CENCAM. Pictured here, members of the organizing committee and other collaborators from left to right: Brittany…

1. IntroductionHeart failure is a severe and harmful syndrome with high mortality and morbidity rates, that are higher among the older population, but not yet well defined since the true prevalence and incidence of this syndrome is not…

IJERPH, Vol. 21, Pages 152: A Sex- and Gender-Based Approach to Chronic Conditions in Central Catalonia (Spain): A Descriptive Cross-Sectional Study International Journal of Environmental Research and Public Health doi:…

By Ian Trabuco, as told to Hallie LevineI’ve been living with chronic migraines for 3 years. They began my junior year of high school. The symptoms go well beyond just a headache. When I’m in the full throes of a migraine attack, I feel…

By Merle L. Diamond, MD, as told to Kara Mayer RobinsonAs a physician and lecturer specializing in headache medicine, I’m always looking for ways to help patients better manage chronic migraine. Chronic migraine means you have more than…

By Katie M. Golden, as told to Kara Mayer RobinsonAs someone living with chronic migraine, every day is different. There’s no cure for this genetic neurologic disease, but there are things I do to manage my day-to-day life.I'm 40 years…