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Global Health Threats
Drug candidate may ‘unmask’ latent HIV-infected cells, mark them for destruction
Credit: Miguel Á. Padriñán from Pexels
University of Pittsburgh School of Medicine scientists have identified drug candidates that show…
Small protein plays big role in chronic HIV infection
Differential gene expression associated with GABA and glutamate neurotransmission systems in the cortex and hippocampus. Clustergram heat map of mRNA expression of…
Using machine learning to track the evolution of COVID-19
The Left panel shows a cartoon representation of the nsp12-nsp8-nsp7-RNA complex (PDB code 6YYT), with nsp12 colored by domains (NiRAN in gray, interface in white,…
Birth rate in United States remained unchanged from 2021 to 2022, report shows
The birth rate in the United States was essentially unchanged from 2021 to 2022, according to the April 4 National Vital Statistics Reports.…
How do wildfires affect mental health? A new study examines the connection
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Checking air quality and staying indoors when smoke inundates the Seattle area has become second nature…
Five-year interval is safe for prostate cancer screening, research shows
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A simple blood test every five years is sufficient to screen low risk men for prostate cancer, new research has…
Dogs may provide new insights into human aging and cognition
The quest to understand intelligence and unravel the workings of the mind has always been considered the holy grail of natural sciences. While we're still…
Lifetime of stress takes toll on cardiovascular health of Black Americans
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Daily and lifetime exposure to stress may cause wear and tear on the stress responses of Black…
Early 3D chromatin remodeling to trigger cellular stress response
TAD dynamics along p53 activation. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-46666-1
The simplest explanation of…
Research team builds first tandem repeat expansions genetic reference maps
Graphical abstract. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.03.004
A research team led by the University of California, Irvine has…
New study reveals how T cells gain and maintain tolerance to gut bacteria
Enrichment of the LA cell signature by spatial transcriptomics analysis is diminished in inflammation. Credit: Nature (2024). DOI: 10.1038/s41586-024-07251-0…
Blast exposure linked to intestinal problems
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A study by New York and Rocky Mountain U.S. Department of Veterans Affairs researchers showed blast…
Earlier menopause plus high cardiovascular risk may lead to cognitive problems later
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Earlier menopause combined with higher risk of cardiovascular disease is linked to an increased risk of…
Study reveals genetic drivers of metabolic dysfunction-associated steatotic liver disease
Overview of the study design. Credit: Life Science Alliance (2024). DOI: 10.26508/lsa.202302517
In the largest study of its kind,…
Platform tracks SARS-CoV-2 mutational impact on disease severity, identifies effective therapeutic…
A droplet microfluidics-based system for high-throughput screening of syncytium formation. a, Co-culture of spike-expressing sender cells (mCherry+) and…
More awareness and investment needed to support people with long COVID, says report
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More long COVID awareness and education is needed among doctors, nurses, care providers and the public…
New insights into adult-onset type 1 diabetes
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Type 1 diabetes, a chronic condition affecting millions of young individuals globally, is not exclusive…
Few newly diagnosed type 2 diabetics succeed in losing weight, study shows
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A registry-based study from Finland identified three distinct BMI trajectory groups among patients with…
Research team discovers new method to test for oral cancer
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Oral cancers and precancerous mouth lesions are considered especially difficult to diagnose early and…
App designed for dental teams offers step-by-step guidance in an emergency
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In a crisis, a checklist can bring clarity over confusion. First widely adopted by the U.S. military…
Researchers say around 10% of deaths from coronary stenting, balloon angioplasty are preventable
Credit: Justine Ross, Jacob Dwyer: Michigan Medicine
Each year more than 500,000 Americans undergo percutaneous coronary intervention, or…
Review identifies disrupted mitochondrial metabolism as a trigger for diabetic cardiomyopathy
In diabetic hearts, ATP production fails to meet demands due to altered mitochondria and substrate utilization. Early diabetes triggers metabolic issues,…
Researchers unveil faster and more accurate COVID test
Schematic illustration of direct quantitative detection from HNS specimens using SERS and DLAs. Credit: Advanced Materials Interfaces (2024). DOI:…
Engineers create 3D-bioprinted blood vessel
Credit: ESA-SJM Photography
The model blood vessel was made using 3D bioprinting to help investigate how weightlessness changes the…
Is eye movement in autism tied to facial recognition?
Eye movement patterns are summarized with a hidden Markov model (HMM). HMM parameters include ROIs (Gaussian emissions), which are derived from underlying fixation…
Chemical regulates light processing differently in the autistic and non-autistic eye, new study…
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King's College London researchers have shown that the brain chemical GABA regulates activity in the…
ADHD medication linked to reduced mortality
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Researchers from Karolinska Institutet have shown a link between use of medication for ADHD and a…
Autism and ADHD are linked to disturbed gut flora very early in life
Credit: Cell (2024). DOI: 10.1016/j.cell.2024.02.035
Disturbed gut flora during the first years of life is associated with diagnoses such…
Despite their prevalence, arthritis, neck and back pain receive few research dollars, analysis finds
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Musculoskeletal diseases—a diverse category of conditions affecting bones, joints, muscles, and…
Knees stiff with arthritis? Company studies whether fat injections can improve motion
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A Louisville, Colorado, company is studying whether cells taken from patients' fat could reduce knee…
Immunotherapy for Alzheimer’s disease shows promise in mouse study
Scientists at Washington University School of Medicine in St. Louis have shown that treating mice with an antibody that blocks the interaction between APOE proteins…
A potential method for interrupting the misfolding of tau protein that underlies neurodegenerative…
Investigation of the effect of VHH Z70 nanobody on jR2R3 P301L-induced tau fibrillization in cells. Credit: Proceedings of the National Academy of Sciences (2024).…
Reducing late-night alcohol sales curbed all violent crimes by 23% annually in a Baltimore…
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Simply reducing the hours during which alcohol may be purchased can significantly reduce violent crime,…
New book challenges the assumption that youth drinking is in decline globally
Credit: Palgrave Macmillan
The harmful use of alcohol causes an estimated 3 million deaths every year, of which a significant proportion…
Suicides among US college student athletes have doubled over past 20 years: Study
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The number of suicides among US college student athletes has doubled over the past 20 years, finds an…
Bladder cancer treatment can be better targeted and more effective, trials show
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Testing for tumor DNA in the blood can successfully identify advanced bladder cancer patients who will…
Gender Differences in Emotional Responses May Start in the Womb
Research Suggests Hormonal Exposures In-Utero Influence Mental HealthBy Brandon LevyTuesday, April 2, 2024
A recent IRP study suggests that exposure to certain hormones in-utero may influence the developing brain in ways that contribute…
Changes Coming to Applications and Peer Review in January 2025 – NIH Extramural Nexus
Posted April 4, 2024April 4, 2024
NIH is implementing multiple changes that will impact the preparation and peer review of most grant applications submitted to NIH for due dates on or after January 25, 2025. Although each of these…
LEVONORGESTREL AND ETHINYL ESTRADIOL kit
This product (like all oral-contraceptives) is intended to prevent pregnancy. Oral-contraceptives do not protect against transmission of HIV (AIDS) and other sexually transmitted diseases (STDs) such as chlamydia, genital herpes,…
Advanced Search, History, and Search Details. NLM Technical Bulletin. 2019 Mar–Apr
Chan J. PubMed Labs Update: Advanced Search, History, and Search Details. NLM Tech Bull. 2019 Mar-Apr;(427):e3.
The National Library of Medicine (NLM) is continuing to develop features on the PubMed Labs platform, and this new version…
Environmental Factor – April 2024: In Salt Lake City, SOT conference showcases innovative…
At the 63rd annual meeting of the Society of Toxicology (SOT) held March 10-14 in Salt Lake City, Utah, NIEHS scientists and staff presented cutting-edge research on artificial intelligence (AI), neurotoxicity testing, harmful algal…
Environmental Factor – April 2024: Grantee shines new light on cause of ciguatera seafood…
Ciguatera poisoning is the most common non-bacterial seafood-borne illness in the world. More than 50,000 cases are reported annually, but scientists think that the true numbers may be much higher, because the symptoms — vomiting,…
Remote Sensing | Free Full-Text
1. IntroductionA hyperspectral image (HSI) is a three-dimensional cube composed of spectral and spatial information. Among them, the spectral information consists of hundreds of continuous narrow bands that record the reflectance values…
Biomedicines | Free Full-Text | T Cell Receptor-Directed Bispecific T Cell Engager Targeting…
1. IntroductionThe T cell engager (TCE), which redirects cytotoxic T cells to kill tumor cells, is emerging as a promising strategy to treat cancer patients, especially those with a low-mutation-burden tumor or a low number of…
Cancers | Free Full-Text | Dermoscopy as a Tool for Identifying Potentially Metastatic Thin…
1. IntroductionThe incidence of melanoma is rapidly increasing worldwide, and it is one of the most frequent tumors affecting young people. In Italy, it represents the second most frequent tumor in men < 50 years and the third most…
Healthcare | Free Full-Text | The Safety of Peripheral Nerve Blocks: The Role of Triple Monitoring…
Regional anaesthesia involves the reversible blocking of the conduction of pain stimuli in nerve fibres by injecting local anaesthetic drugs into their vicinity.Local anaesthetics block the sodium channels and cause the inhibition of…
JCM | Free Full-Text | Contrast-Induced Acute Kidney Injury in Patients with Heart Failure on…
2. Materials and Methods 2.1. Study PopulationThis single-center, retrospective study enrolled all consecutive patients with HF undergoing ICM invasive procedures at Careggi University Hospital from January 2019 to December 2023,…
JPM | Free Full-Text | Elucidating the Impact of Deleterious Mutations on IGHG1 and Their…
1. IntroductionHuntington’s disease (HD) presents an enduring challenge within the landscape of neurodegenerative disorders . It is a hereditary disorder characterized by a relentless progression of motor dysfunction, cognitive…
Vaccines | Free Full-Text | “You Don’t Know If It’s the Truth or a Lie”: Exploring Human…
1. IntroductionThe World Health Organization (WHO) considers vaccine hesitancy as one of the top threats to global health . Vaccine hesitancy, defined as a “reluctance or refusal to vaccinate despite the availability of vaccines”,…
Viruses | Free Full-Text | A Comparative Study of Human Pluripotent Stem Cell-Derived Macrophages in…
H1 cells and induced pluripotent stem cells (iPSCs) culture, macrophage differentiation, co-culture with Huh7 cells, flow cytometry analysis, and immunofluorescence were performed as described previously . The H1 cells (WiCell Research…