Expression

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FLORENCE, Italy —  Michelangelo's David has been a towering figure in Italian culture since its completion in 1504. But in the current era of the quick buck, curators worry the marble statue's religious and political significance is…

1. IntroductionThymic epithelial tumors (TETs) are the most common mediastinal neoplasms, presenting clinicopathological and molecular heterogeneity. The most recent WHO classification divides them into six major histological subtypes,…

1. IntroductionLipids are essential for various cellular functions, including energy homeostasis, membrane remodeling, and lipid signaling . In plant cells, lipids are primarily found in the form of triacylglycerol (TAG), which is…

1. IntroductionCodon usage is one of the factors influencing the amount of polypeptide produced per mRNA in bacteria and eukaryotic cells, and tRNA abundance seems to be a major factor in this process . The relative deficiency of…

1. IntroductionDespite all the advances in the control of HIV-1 infection, the virus remains a major public health problem worldwide, with an estimated 1.3 million new infections each year . Because there is still no treatment available…

Many pieces of evidence support the hypothesis that miRNAs are deregulated in all hallmarks of cancers. In this Special Issue, you can find some papers that show how miRNAs can act as both villains and heroes in different types of…

1. IntroductionThe Severe Acute Respiratory Syndrome–Coronavirus-2 (SARS-CoV-2) is the aetiologic agent of COVID-19, a pandemic disease, which started in China at the end of 2019, spread worldwide and caused, as of last December, nearly…

Virus assembly requires the coordinated synthesis and interaction of several gene products. Bluetongue virus (BTV) is a prime example of this architectural complexity, with virions composed of two concentric shells, the outer capsid…

IntroductionIn beef production, the cost of feeding is a crucial factor that significantly impacts the overall cost of production. Studies have demonstrated that feed cost accounts for 60 to 70% of the total expenses in animal production…

1 Introduction As the population ages, the rates of neurodegenerative disorders and dementia increase, with the number of individuals worldwide living with dementia expected to triple by 2050 (World Health Organization, 2022). With…

In the current retrospective analysis, we tried to simulate the control group of the PACIFIC study and test for differences in the OS relative to PD-L1 expression. No differences in the OS between PD-L1 <1% and ≥1% were found.Also, no…

All together the findings presented here suggest that in the course of simple obesity in children, systemic inflammatory reactions may be rather limited. It was reflected here by decline in leukocyte MMP2 expression, decreased serum MMP2…

1. IntroductionThe assessment of breast cancer (BC) histological grade and biomarker expression has become routine practice in clinical pathology. The histological grading of BC is one of the strongest prognostic factors and has been…

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Biology 2024, 13(3), 191; https://doi.org/10.3390/biology13030191 (registering DOI) Submission received: 13 February 2024 / Accepted: 15…

1. IntroductionThyroid cancer (TC) is the most frequently diagnosed endocrine-related malignancy, accounting for about 3–4% of all human cancers . Based on its histology, TC originating from follicular cells can be classified as either…

1. IntroductionThe medial collateral ligament (MCL) plays a crucial role in stabilizing the knee joint. It runs along the inner side of the knee, connecting the femur to the tibia. MCL injuries are prevalent, accounting for…

1 Introduction High-throughput sequencing data is being generated in large amounts, Reuter et al. (2015) creating an exponential increase in experimental gene expression data (Giles et al., 2017). Millions of freely accessible -omic…

The regulation of gene expression is primarily achieved through cis-acting elements, and understanding how these elements are regulated by cellular signaling pathways is crucial for revealing the functions of these genes in different…

1. IntroductionPrimary hypertension (PH) is an etiologically complex syndrome. There is a hypothesis called the Page mosaic theory. The theory explains that at least three critical systems (excluding genetic and environmental factors),…

1. IntroductionAdventitious roots are produced from non-middle column sheath tissues such as stems or leaves of plants . The occurrence of adventitious roots is a critical factor for successful asexual propagation of plants. The…

1. IntroductionPears are cultivated from perennial fruit trees belonging to the Pyrus L. genus (Rosaceae), representing one of the most extensively planted fruit trees globally. In China, pears rank third in fruit production, following…

NIEHS scientists developed an application that enables users to quickly assess gene interactions without having a background in computer programming or statistical modeling. Structural Equation Modeling of In silico Perturbations…

1. IntroductionKeratoconus (KC) is a bilateral, asymmetric disease involving the progressive thinning and steepening of the central and paracentral part of the cornea, which takes the shape of a cone. The result of these changes is a…

1. IntroductionSARS-CoV-2, a single stranded positive RNA-virus, emerged in 2019. Infection is caused via the binding of the virus to the angiotensin-converting enzyme 2 (ACE2) receptors expressed on the epithelial cells in the upper…

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Biomedicines 2024, 12(2), 427; https://doi.org/10.3390/biomedicines12020427 (registering DOI) Submission received: 14 January 2024 /…

1. IntroductionOver four years have elapsed since the emergence of the new Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus, impacting over 700 million people globally . Despite the World Health Organization officially…

1. IntroductionGlycosyltransferases (GTs) are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, playing vital roles in the biosynthesis of carbohydrates, lipids,…

1. IntroductionSystemic inflammation without evident clinical infection is common in CKD patients . This can exacerbate various pre-existing comorbidities such as cardiovascular disease, malnutrition and erythropoietin-resistant anemia,…

1. IntroductionBreast cancer is a highly heterogeneous disease. Using gene expression profiles or immunophenotypic characteristics, different molecular subtypes of breast cancer have been identified, thus allowing for a refined…

1. IntroductionExcessive alcohol consumption is a longstanding, significant public health issue experienced worldwide . In Canada, data from the 2019–2020 Canadian Postsecondary Education Alcohol and Drug Use Survey (CPEADS) revealed…

Sequencing all of the RNA in a cell can reveal a great deal of information about that cell’s function and what it is doing at a given point in time. However, the sequencing process destroys the cell, making it…

1. IntroductionThyroid cancer (TC) represents presently the most prevalent endocrine malignancy, with an incidence that has increased rapidly in recent decades . Follicular cell-derived tumours constitute the majority of thyroid…

Anita Hopper, Ph.D., shared insights into how transfer ribonucleic acid (tRNA) responds to environmental stressors during the NIEHS Distinguished Lecture held March 14. The Ohio State University professor described how different tRNAs,…

Plant traits are determined by gene expression and environmental factors, which reflect the morphology, function, and adaptability of plants . Gene expression refers to the activity of genes at the transcriptional level, which determines…

The April 11 Dr. Martin Rodbell Lecture Series Seminar featured Joanna Wysocka, Ph.D., a professor of developmental biology at Stanford University, who presented “Making Faces: Transcriptional Enhancers in Human Development, Disease, and…

Author ContributionsConceptualization, X.Z., W.Z., Z.J. and T.H.; methodology, X.Z, W.Z., Y.C. and Y.M.; resources, X.Z., W.Z. and Y.D.; software, X.Z., N.Z., Y.B. and Y.C.; validation, X.Z., W.Z., Y.C. and Y.D.; data curation, X.Z.,…

1. IntroductionEndometriosis is a chronic disease manifested in a condition where tissue similar to the endometrium of the uterus grows outside the uterine cavity . Endometrial ectopic tissue contains glands and stroma and is capable of…

1. IntroductionEndometriosis is a chronic disease manifested in a condition where tissue similar to the endometrium of the uterus grows outside the uterine cavity . Endometrial ectopic tissue contains glands and stroma and is capable of…

2.1. BackgroundHydrodynamic research on alluvial rivers often involves parameters such as velocity, discharge, stream power, etc., which are primarily obtained based on long-term hydrological data observations at fixed cross-sections of…

Figure 1. An Original and Commonly Used rBEV (Bacmid) RepCap Dual Cassette Design for Producing rAAV Sf9 Cells. The overlapping Rep78/Rep52 and Cap-related VP1/VP2/VP3/AAP genes are shown in context with the bipartite baculovirus very…

1. IntroductionHead and neck squamous cell carcinoma (HNSCC) represents the 8th most common cancer entity worldwide, accounting for more than 878,000 new cases and 444,000 deaths in 2020 . Most patients are diagnosed in advanced stages…

taRNAs built from an array of IRESs increase reporter gene translation. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-42252-z…

1 IntroductionEczema or atopic dermatitis (AD) is a chronic inflammatory skin condition manifesting as intermittent flares of itchy skin. The lifetime prevalence is roughly 15%–30% in children and adolescents and 2%–10% in adults (1).…

Credit: Pixabay/CC0 Public Domain As possibilities have changed and technology has advanced, memories and nostalgia are now a significant…

KYAN Technologies,Alentis Therapeutics,and CELLphenomics Join Forces Combining Cutting-edge Optim.AI™ and PD3D® Models to Advance Claudin-1 Expression Research SINGAPORE, SINGAPORE, September 30, 2023 /EINPresswire.com/ -- KYAN…