gene

Author ContributionsAll authors contributed to the study conception and design. Conceptualization: K.-i.N.; Formal analysis: M.H., T.T., M.K., T.F., M.T., and H.S.; Funding acquisition: K.-i.N.; Investigation: M.H., S.S., N.U., T.T., and…

Dr. Chelisa Cardinez (pictured) says the discovery finally provides an explanation for why patients with psoriasis may go on to develop psoriatic arthritis, leaving…

Credit: Pixabay/CC0 Public Domain New research presented early ahead of this year's European Congress of Clinical Microbiology and…

Many pieces of evidence support the hypothesis that miRNAs are deregulated in all hallmarks of cancers. In this Special Issue, you can find some papers that show how miRNAs can act as both villains and heroes in different types of…

News ReleaseWednesday, March 20, 2024 Treatment for rare childhood disease was well tolerated and slowed loss of motor function. An investigational gene therapy for a rare neurodegenerative disease that begins…

Credit: CC0 Public Domain Early stages of neurodegenerative disorders are characterized by the accumulation of proteins in discrete…

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Biology 2024, 13(3), 191; https://doi.org/10.3390/biology13030191 (registering DOI) Submission received: 13 February 2024 / Accepted: 15…

Author ContributionsConceptualization, Y.L., Z.L. (Zizhen Liang) and Y.Y.; methodology, Z.L. (Zizhen Liang) validation, Y.L., Z.L. (Zizhen Liang) and S.Y.; investigation, Y.L. and Z.L. (Zizhen Liang); resources, Y.L., Z.L. (Zizhen Liang)…

Gene frequencies of the CYP7A1 gene polymorphisms in ACS patients and the controls were in Hardy–Weinberg equilibrium. Only two polymorphisms (rs3808607 G/T and rs1457043 C/T) out of the seven polymorphisms studied in this work were not…

1 Introduction High-throughput sequencing data is being generated in large amounts, Reuter et al. (2015) creating an exponential increase in experimental gene expression data (Giles et al., 2017). Millions of freely accessible -omic…

MENLO PARK, Calif.--(BUSINESS WIRE)--Grace Science, LLC announced today that the first patient was dosed in an open-label Phase 1/2/3 clinical trial of GS-100, an AAV9 gene replacement therapy for the treatment of NGLY1 Deficiency. Part…

Neuron showing SynGAP (green) binding to PSD-95 at synapses. Credit: Yoichi Araki and Rick Huganir, Johns Hopkins Medicine Johns Hopkins…

DUBLIN--(BUSINESS WIRE)--The "Human Gene Sequencing Markets, Strategies & Trends - Forecasts by Application, by Technology, by Workflow, by Product, and by Country, with Executive and Consultant Guides - 2023 to 2027" report has been…

1. IntroductionMyopia is a common refractive error that is characterized by an optical condition in which the parallel light rays entering the eye converge in front of the retina . Myopia is usually caused by an enlarged intraocular…

1 Introduction Alzheimer’s disease (AD) is a progressive neurodegenerative disease accounting for up to 60–80% of the total dementia cases (Alzheimer's Association, 2021). According to a 2019 statistics, the worldwide cost of…

1. IntroductionPears are cultivated from perennial fruit trees belonging to the Pyrus L. genus (Rosaceae), representing one of the most extensively planted fruit trees globally. In China, pears rank third in fruit production, following…

NIEHS scientists developed an application that enables users to quickly assess gene interactions without having a background in computer programming or statistical modeling. Structural Equation Modeling of In silico Perturbations…

1. IntroductionYellowhorn (Xanthoceras sorbifolia Bunge) is a perennial woody plant that belongs to the Sapindaceae family and is native to northern and northwestern China . In semi-arid and dry environments, yellowhorn is considered a…

BERLIN & RESEARCH TRIANGLE PARK, N.C.--(BUSINESS WIRE)--Bayer AG and Asklepios BioPharmaceutical, Inc. (AskBio), a gene therapy company wholly owned and independently operated as a subsidiary of Bayer AG, today announced that the…

1. Introduction 1.1. Aim of the StudyThis study aimed to assess the current level of accessibility of gene therapy medicinal products (GTs) in Bulgaria, with a specific emphasis on the different legal tools to access GTs and their…

Revised- Gene regulatiion Eukaryotics.pdfRevised- Gene regulatiion Eukaryotics.pdf2. Introduction  Gene regulation is a fundamental process that allows an organism to control the expression of its genes, determining when and to what…

CORVALLIS, Ore. – The discovery of a new gene in zebrafish could lead to a better understanding of how exposure to chemicals leads to disease in humans, according to a new Oregon State University study. The National Institutes of…

A new therapy makes cuts in the gene for kallikrein (shown as graphics), a protein involved in inflammationBIOSYM TECHNOLOGIES, INC./SCIENCE PHOTO LIBRARY Nine people with a rare genetic condition that causes…

A new therapy makes cuts in the gene for kallikrein (shown as graphics), a protein involved in inflammationBIOSYM TECHNOLOGIES, INC./SCIENCE PHOTO LIBRARY Nine people with a rare genetic condition that causes…

1. IntroductionThe ubiquitin-26S proteasome system (UPS) is one of the most important protein degradation systems in eukaryotes. About 80% of proteins are degraded by the ubiquitin–proteasome pathway . Ubiquitination specifically…

ProteinVAE architecture. Encoder: pre-trained language model (for example, ProtBert) converts the input one-hot-encoded sequences to amino-acid-level representation H.…

On April 13, renowned scientist Richard Young, Ph.D., from the Massachusetts Institute of Technology (MIT), presented “Nuclear Condensates in Gene Regulation and Disease” as part of the NIEHS Distinguished Lecture Series. He is a…

PET scan of a human brain with Alzheimer's disease. Credit: public domain Within our brain cells, there exists a highway system of…

Sequencing all of the RNA in a cell can reveal a great deal of information about that cell’s function and what it is doing at a given point in time. However, the sequencing process destroys the cell, making it…

Characterization of the human primary olfactory mucosal cells at air–liquid interface. Credit: Journal of Neuroinflammation (2023). DOI: 10.1186/s12974-023-02979-4…

DNA methylation is an important form of an epigenetic modification widely found in plant genomes, and it regulates the expression of genes in various developmental periods, as well as in different plant tissues . There are three main…

Anita Hopper, Ph.D., shared insights into how transfer ribonucleic acid (tRNA) responds to environmental stressors during the NIEHS Distinguished Lecture held March 14. The Ohio State University professor described how different tRNAs,…

The April 11 Dr. Martin Rodbell Lecture Series Seminar featured Joanna Wysocka, Ph.D., a professor of developmental biology at Stanford University, who presented “Making Faces: Transcriptional Enhancers in Human Development, Disease, and…

2.1. PublicationsThe advancements and applications of gene therapy can be reflected in yearly publications (Figure 2). Publications mentioning “gene therapy” date back to the 1970s (1922 total papers) but expanded rapidly in the 1990s…

Author ContributionsConceptualization, X.Z., W.Z., Z.J. and T.H.; methodology, X.Z, W.Z., Y.C. and Y.M.; resources, X.Z., W.Z. and Y.D.; software, X.Z., N.Z., Y.B. and Y.C.; validation, X.Z., W.Z., Y.C. and Y.D.; data curation, X.Z.,…

2.1. Study Design and Baseline Screening ProcedureBetween June to August in 2018, a total of 2000 women aged 25–64 from Tuoli County, Xinjiang, China, were recruited to this prospective cervical cancer screening cohort study. Details on…

1. IntroductionResponses to COVID-19 are variable: most SARS-CoV-2-infected individuals have mild or no symptoms, but in ~10–15% of cases COVID-19 patients progress to severe disease, in ~5% to critical disease and in ~1.3% to lethality…

Materials and MethodsA full eye examination was carried out on the patient. This included ophthalmoscopy (fundus examination), electrophysiological examination, computer perimetry, ultrasound examination (B-scan), visometry,…

HYPERTENSION: FROM GENE TO COMMUNITY Loading... Loading video...…

On January 25, 2023, this report was posted online as an MMWR Early Release.Heather M. Scobie, PhD1; Akilah R. Ali, MPH1; Philip Shirk, PhD1; Zachary R. Smith, MA2; Prabasaj Paul, PhD3; Clinton R. Paden, PhD1; Norman Hassell, MS1;…

The quantum-classical framework using the qscGRN model to infer the corresponding biological GRN. Credit: npj Quantum Information (2023). DOI:…

taRNAs built from an array of IRESs increase reporter gene translation. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-42252-z…

The information on this website is not intended for diagnostic use or medical decision-making without review by a qualified health care professional. Individuals should not change their health behavior solely on the basis of information…

A new analysis helps to unravel the mystery of the Australian dingo’s origins by showing that it is probably descended from a wild…

People with recessive dystrophic epidermolysis bullosa, a genetic condition that causes widespread skin blistering, have been…

Wildlife photographers spotted an unusually pale, red-eyed turtle hatchling in Telangana state, which was identified as a flapshell…

The current reference human genome is based on a handful of people but the new Pangenome project will incorporate DNA from hundreds…

The remnants of a virus that plagued our mammal ancestors during the age of the dinosaurs have been found lurking in our genomes…

POLITICO's Mike Allen talks with Gene Karpinski, President of the League of Conservation Voters, about their plan for 2014, from continuing the push to reject the Keystone pipeline, to supporting candidates running against 'climate change…