Enrichment of the LA cell signature by spatial transcriptomics analysis is diminished in inflammation. Credit: Nature (2024). DOI: 10.1038/s41586-024-07251-0…
Pete Townshend’s prescient 1967 rock opera, “The Who’s Tommy,” a horrifying if ultimately transcendent howl of anger and anguish at the damage wrought on the boomer generation by their war-scarred parents, has returned to Broadway in a…
1. IntroductionVaccinations have transformed public health, notably since the 1960s, when national vaccination programs were established. According to World Health Organization data, vaccination programs prevent 2–3 million deaths each…
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Biomedicines 2024, 12(3), 703; https://doi.org/10.3390/biomedicines12030703 (registering DOI)
Submission received: 30 January 2024
/…
1. IntroductionThe continuous self-renewal of the intestinal stem cells (ISCs) underpins the high turnover rate of differentiated epithelial cells . Over a decade ago, Hans and colleagues demonstrated how ISCs self-renew and proliferate…
1. IntroductionApproximately ten trillion microbial cells colonize the gastrointestinal tract, especially the gut, where they carry out various physiological functions impacting the host’s health, such as the fermentation of…
Faeces reveals the bacteria in our gut, but we don’t yet know which are optimalSTEVE GSCHMEISSNER/Science Photo Library/Alamy
The science of our gut microbiome is often painted as one of the hottest new areas of…
It is well known that the pancreas influences the microbiota directly through the secretion of antimicrobial peptides, and indirectly through the involvement of pancreatic enzymes in the digestion process, thus playing an important role…
March 13, 2024
“Republicans are outraged about modest help for our most vulnerable children. At the same time, they are shamelessly fighting for billions of dollars in retroactive tax breaks for a handful of…
Top-prescribed drugs elicit rich transcriptomic responses from prevalent gut bacterial species. a, Schematic of our high-throughput transcriptomic pipeline for…
1. IntroductionIn recent decades, the amount of allergic reactions among the child population has increased. The most common manifestations of immune system disorders are food allergies and atopic dermatitis, which often occur together…
1. IntroductionAfter birth, the colonization of the gut microbiota is influenced by organ maturity and external factors such as delivery method, antibiotic treatments, and choice of feeding method . The time from birth to the…
Feb. 22, 2024 -- Injectable weight loss drugs like Wegovy, Saxenda, and Zepbound have been getting all the glory lately, but they’re not for everyone. If the inconvenience or cost of weight-loss drugs isn't for you, another approach may…
How serotonin produced in the gut can influence mood and gastrointestinal disorders was the focus of a Jan. 12 NIEHS cross-divisional seminar by Kara Margolis, M.D., from Columbia University’s Irving Medical Center. Her talk centered on…
1. IntroductionOver four years have elapsed since the emergence of the new Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus, impacting over 700 million people globally . Despite the World Health Organization officially…
1 IntroductionThe intestinal structure is essential for health and performance of all animals. The epithelial lining in the intestine has an important role in integrity and body defense locally (Eckmann, 1995; Pitman and Blumberg, 2000).…
Streptococcus sanguinis bacteria, which live in the mouth, may host replicators named obelisksUK HEALTH SECURITY AGENCY/SCIENCE PHOTO LIBRARY
A previously unknown type of replicating agent, far smaller and simpler…
Several thousand strains of bacteria live in the human gut. Some of these are associated with disease, while others have beneficial effects on human health. Figuring out the precise role of each of these bacteria…
1. IntroductionAdverse childhood experiences (ACEs) encompass abuse (emotional, physical, and sexual), neglect, and household dysfunction . Most adults have encountered at least one ACE , with prevalence at 65–87% . ACE exposure has…
Neurodegenerative diseases (NDs), such as Alzheimer's and Parkinson's disease (PD), are debilitating conditions that affect millions of people worldwide (Ghosh et al., 2020). Research has shown that there is a potential link between…
IntroductionPeople living with HIV in Sub-Saharan Africa (SSA) constitute about 54% of the world’s HIV-infected population (1). The introduction of combination antiretroviral therapy (cART) has reduced the burden of HIV in SSA with a…