Pancreas sections from control and P.gingivalis-infected mice. Control mouse showing a small pre-cancerous lesion (marked in yellow). Credit: Hebrew University of…
1. IntroductionThe oral pathogenic bacteria Selenomonas noxia has been associated with the development and progress of periodontal disease, along with other gram-negative organisms such as Porphyromonas gingivalis, Treponema denticola,…
1. IntroductionStress is a response primarily regulated by the autonomic nervous system and the hypothalamic–pituitary–adrenal axis . This response evolves to adapt to the demands imposed by an individual’s stimulating and ever-changing…
Washington, D.C., March 18, 2024 (GLOBE NEWSWIRE) -- Today, the Supreme Court heard oral argument in the New Civil Liberties Alliance’s Murthy v. Missouri case, considering whether to uphold a historic preliminary injunction granted…
1. IntroductionOral squamous cell carcinoma (OSCC) is a malignant epithelial tumor arising from the mucosal surfaces of the oral cavity. Despite advances in treatment, OSCC continues to have poor survival rates, with a 5-year survival…
1. IntroductionOral potentially malignant disorders (OPMDs) are precursors of over 80% of oral cancers with reported malignant transformation rates ranging from 3 to 34%, correlating with the grade of dysplasia and prognostic…
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1,2,*, 2, 2,3, 4, 5, 6, 7 and 8,9,*
1
Department of Clinical Oncology, Wroclaw Medical…
– STRIDE Phase 2 primary endpoint of PASI 75 and key secondary endpoints met at all clinically relevant doses tested; sustained maximal target inhibition safely achieved at top dose – – Open label extension (OLE) study data to…
Your mouth is a crucial interface between the outside world and the inside of your body. Everything you breathe, chew, or drink interacts with your oral cavity — the proteins and the microbes, including microbes…
1. IntroductionBone dysplasia (BD) comprises a group of rare genetic diseases (affecting less than 1 in 200,000) characterized by abnormalities in bone development and structure . These disorders often appear during childhood and can…
Researchers at the NIEHS-funded Louisiana State University (LSU) Superfund Research Program (SRP) Center recently used community interview data to reveal historical effects of a thermal treatment waste facility on residents in Colfax,…
Washington, D.C., Feb. 28, 2024 (GLOBE NEWSWIRE) -- Today, former Texas Solicitor General Jonathan Mitchell presented oral argument to the Supreme Court in the New Civil Liberties Alliance’s Garland v. Cargill case, demonstrating that…
1 Introduction
Oral cancer represents the sixteenth most deadly type of cancer worldwide and represents a serious and growing public health problem (IARC-OMS, 2020). A significant part of oral cancers develop from potentially malignant…
1. IntroductionThe approach in the healthcare system has evolved over time, shifting from a narrow focus—that targeted individual disease prevention—to a more comprehensive guide on human well-being . In the past, health studies focused…
1. IntroductionRecent reports by several international organizations have highlighted the important and crucial contributions that Indigenous Peoples and Local Communities (IPLCs) make to the conservation and stewardship of the world’s…
1. IntroductionOral health is an essential part of healthy aging and oral disease among the aging global population, and has led to an estimated 28.02% increase in Disability Adjusted Life Years (DALY) for older adults between 1990 and…
1. IntroductionThe incidence of spondylodiscitis in western countries has risen over the past few decades. It is a rare disease with high morbidity and long-term sequelae. Unfortunately, it is often recognized and treated late. The…
1. BackgroundAn umbrella term, intellectual and developmental disabilities are lifelong disabilities that start in childhood and limits the person’s functioning in communication, mobility, self-care and learning . The health disparities…
BERLIN & SAN DIEGO--(BUSINESS WIRE)--Vividion Therapeutics, Inc. (Vividion), announced today that it has initiated dosing of patients in a Phase I clinical trial evaluating VVD-130850, an investigational oral STAT3 inhibitor for the…
ObjectivesIn 2008, Florida's Medicaid program began reimbursing medical providers for preventive oral health services (POHS) delivered to children aged 6 months to 42 months. We examine whether Medicaid comprehensive managed care (CMC)…
This story was originally published in the Forward. Click here to get the Forward’s free email newsletters delivered to your inbox.
One of Curb Your Enthusiasm’s most beloved episodes had been rattling around its…
BackgroundThe COVID-19 pandemic created new barriers to oral health care, which may worsen oral health and exacerbate disparities. The authors quantified changes in children's dental care receipt and oral health outcomes during the…
1. IntroductionChikungunya virus (CHIKV) is an alphavirus of the Togaviridae family. It was first detected near the border between Tanzania and Mozambique in 1952 . In urban areas, Aedes aegypti and Ae. albopictus mosquitoes are the…
3.2. Model Development and ValidationA summary of the 23 models is presented in detail in Table 1 (phenotypic-only models) and Table 2 (models including genetic risk factors).The most common outcome is OCC (n = 18) , which includes all…
1. IntroductionHeart failure is a severe and harmful syndrome with high mortality and morbidity rates, that are higher among the older population, but not yet well defined since the true prevalence and incidence of this syndrome is not…
1. IntroductionPrimary dentition (baby teeth or milk teeth) is a fundamental stage for the integral development of children, impacting their physical growth, oral function, and psychosocial aspects . However, previous research has…
1. IntroductionPrimary Health Care (PHC) replaced the hospital-centric model and established itself as an organizational strategy to respond to the health needs of the population. In 1990, the Community Health Agent Program (CHAP) was…
Washington, D.C.— In response to today’s oral arguments at the Supreme Court on Relentless, Inc. v. Department of Commerce and Loper Bright Enterprises v. Raimondo, the League of Conservation Voters (LCV) released the following…
Seattle (Jan. 9, 2024) – Seattle City Attorney Ann Davison announced that her office will present oral arguments this morning in an appeal to reverse a federal district court injunction that halts the City of Seattle’s ability to…
1. IntroductionIn contemporary discourse, the paradigm of oral health goes beyond the cosmetic aspect of an esthetically pleasing smile. Beyond the pursuit of white and healthy teeth, oral health is now recognized as a crucial factor in…
Summary
What is already known about this topic?
U.S. children with heart conditions might be at increased risk for infective endocarditis from oral bacteria; however, little is known about their oral health.
What is added by this…
Experts in oral health policy from the Harvard School of Dental Medicine discussed barriers to equitable health care in a webinar hosted by the Office of the Vice Provost for Advances in Learning Wednesday evening.The webinar featured…
3.1. Clinical Presentation, Incidence and RiskAs recalled above, the first approved clinical purpose for an mTORi (sirolimus) was based on its observed immunosuppressive activity in the prevention of solid organ transplant rejection.…
Discussion
Current evidence, including randomized controlled trial and observational data, suggests that SARS-CoV-2 rebound occurs initially as a mild illness 3–7 days after resolution of the initial acute illness, occurs in both…
Javier Martin, PhD1; Cara C. Burns, PhD2; Jaume Jorba, PhD2; Lester M. Shulman, PhD3; Andrew Macadam, PhD1; Dimitra Klapsa, PhD1; Manasi Majumdar, PhD1; James Bullows, PhD4; Ann Frolov, MS4; Ryan Mate, MS1; Erika Bujaki, MS1;…
On June 21, 2022, this report was posted online as an MMWR Early Release.Summary
What is already known about this topic?
Lagevrio and Paxlovid are oral antiviral drugs effective at preventing hospitalization and death in patients with…
Equitable access to COVID-19 therapeutics is a critical aspect of the distribution program led by the U.S. Department of Health and Human Services (HHS).* Two oral antiviral products, nirmatrelvir/ritonavir (Paxlovid)† and molnupiravir…