Differential gene expression associated with GABA and glutamate neurotransmission systems in the cortex and hippocampus. Clustergram heat map of mRNA expression of…
Investigation of the effect of VHH Z70 nanobody on jR2R3 P301L-induced tau fibrillization in cells. Credit: Proceedings of the National Academy of Sciences (2024).…
1. IntroductionCoronavirus disease 19 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Since the publication of the first case in Hubei, China, COVID-19 has reached 772 million confirmed cases and caused 6.9 million…
1. IntroductionDespite improved survival rates for coronary artery disease (CAD) in recent years, CAD overall prevalence remains a significant concern . With the growing number of older people, along with rising rates of diabetes and…
1. IntroductionResponsible for the COVID-19 pandemic, the novel coronavirus 2 (SARS-CoV-2) emerged in Wuhan at the end of 2019 and rapidly spread across the world, impacting the economy and public health . As of November 2023, the WHO…
1. IntroductionBrain sexual dimorphisms notably impact brain anatomy, biochemistry, and various psychological and cognitive processes .Men and women present pronounced differences in the susceptibility, onset, progression, and severity…
In the same way that multiple snapshots of a galloping horse provide information about how the horse moves, multiple snapshots of a protein changing shape can improve…
1 Introduction
Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a neurodegenerative condition that primarily affects motor neurons. This disease is characterized by the progressive degeneration of motor…
1. IntroductionThe Severe Acute Respiratory Syndrome–Coronavirus-2 (SARS-CoV-2) is the aetiologic agent of COVID-19, a pandemic disease, which started in China at the end of 2019, spread worldwide and caused, as of last December, nearly…
1. IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded RNA virus that belongs to the genus betacoronavirus, similar to the previously emerging SARS and Middle East Respiratory Syndrome (MERS)…
1. IntroductionSince its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus responsible for the COVID-19 pandemic , has profoundly affected human health and brought significant…
Chicago, March 21, 2024 (GLOBE NEWSWIRE) -- Organic soy protein isolates are derived from organic soybeans through a process that removes most of the fats and carbohydrates, leaving a highly concentrated protein powder. This isolation…
1. IntroductionCOVID-19 is attributed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which initially emerged in Wuhan, China, and quickly disseminated globally, leading to substantial economic and societal challenges .…
Lyme disease, a bacterial infection transmitted by ticks, affects nearly half a million people in the United States every year. In most cases, antibiotics effectively clear the infection, but for some patients,…
(A) Representative images and quantification of Aβ stained with thioflavin S in the hippocampus and cortex of 5xFAD mice treated with or without APC. (B) Radial arm…
Vancouver, BC, March 12, 2024 (GLOBE NEWSWIRE) -- The demand for a wide variety of flavourful, affordable protein options is rising across Canada. Today, Protein Industries Canada announced a new project to help meet the growing need…
1. IntroductionHuman respiratory syncytial virus (RSV) is an enveloped, negative-sense single-stranded RNA virus belonging to the Pneumoviridae family. It is among the leading causes of lower respiratory tract infections, including…
Researchers in the Cochran lab, including Jack Silberstein (center), led the effort to capture an atomic-scale snapshot of the protein LAG-3. This protein has recently gained popularity for use in certain cancer treatments…
Credit: CC0 Public Domain
Insights into the workings of an immune cell surface receptor, called PD-1, reveal how treatments that restrict its action can potentially be strengthened to improve their…
Winnipeg, MB, March 06, 2024 (GLOBE NEWSWIRE) -- Today, Protein Industries Canada announced a new co-investment into advancing the Canadian fava bean ecosystem. Building on the success of past projects, partners Prairie Fava, DL Seeds…
In the original publication , there was an honest mistake in Figure 4D (P-AKT panel) as published. The P-AKT expression was erroneously duplicated from Figure 5D. The corrected Figure 4D appears below. The authors apologize for any…
A patent search was conducted using the tools from the National Institute of Industrial Property (INPI) , Espacenet , and the World Intellectual Property Organization (WIPO) databases. The keywords were Leishmani*, vaccine, chimer*,…
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Open AccessCommunication
Department of Large Animal and Wildlife Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart…
News ReleaseFriday, March 1, 2024
NIH researchers explore hidden, vulnerable region of influenza neuraminidase.WHAT:
Researchers at the National Institutes of Health have identified antibodies targeting a hard-to-spot…
A tetramer of the influenza neuraminidase protein (shown in blue and light blue) bound by variable domains of two new human antibodies (shown purple/pink and…
Coronavirus 2019 (COVID-19) is a disease caused by the severe respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, which is responsible for the pandemic that started in 2019 . The genetic material of the virus comprises a…
DAVIS, Calif.--(BUSINESS WIRE)--These new tools are particularly useful for designed proteins that don't exist in nature. These are the tools that we need to cure diseases.
1. IntroductionSARS-CoV-2, a single stranded positive RNA-virus, emerged in 2019. Infection is caused via the binding of the virus to the angiotensin-converting enzyme 2 (ACE2) receptors expressed on the epithelial cells in the upper…
Cystic fibrosis (CF) is a genetic recessive inherited disorder affecting an estimated 162,000 people worldwide, with 105,000 of these being diagnosed . The incidence of CF is highly variable geographically. In Europe, for instance, this…
α-Syn(gS87) PFFs have diminished ability to induce pathology formation, spreading and toxicity in cells and in vivo. a, Primary embryonic hippocampal neurons at 7…
Protein importance ranking and SHAP visualization of modeling on all incident dementia populations. a, Sequential forward selection from preselected candidate…
Fibril morphology of third generation seeded fibrils. A) EM images of third generation Aβ42 fibrils prepared using (1) Aβ42 monomers & Aβ42 seeds, (2) Aβ42…
Chicago, Feb. 02, 2024 (GLOBE NEWSWIRE) -- Textured vegetable protein is a plant-based protein product made from defatted soy flour. It is commonly used as a meat substitute or meat extender in various vegetarian and vegan dishes. TVP…
An international team led by scientists at the National Institutes of Health is the first to discover a new way that cells fix an important and dangerous type of DNA damage known as a DNA-protein crosslink (DPC). The researchers found…
Author ContributionsConceptualization, W.-Q.D. and K.M.; Methodology, W.-Q.D., K.B., C.X. and J.S.K.; Validation, K.B.; Formal Analysis, K.B., C.X. and W.-Q.D.; Investigation, K.B. and W.-Q.D.; Resources, W.-Q.D. and K.M.; Data Curation,…
By putting ridges in a plant protein base, cultured muscle cells grew in a pattern that mimics the alignment of muscle fibers in animals. Credit: ACS Biomaterials…
Cognitive trajectory according to Aβ positivity. The y-axis represents the K-MMSE score (a) or CDR-SOB score (b) 3 and 12 months after stroke. Thin and thick lines…
A new Cell Reports paper from Bing Yao’s lab in Emory’s Department of Human Genetics provides insights into mechanisms underlying several neurodegenerative diseases, such as ALS (amyotrophic lateral sclerosis) and Alzheimer’s.It can be…
Researchers from the National Institutes of Health have developed a three-dimensional structure that allows them to see how and where disease mutations on the twinkle protein can lead to mitochondrial diseases. The protein is…
Researchers at the National Institutes of Health and their colleagues have found that a toxic protein made by the body called DUX4 may be the cause of two very different rare genetic disorders. For patients who have…