tumor

Credit: Anna Shvets from Pexels A research group at the Department of Biochemistry and Molecular Biology of the University of Seville has…

1. IntroductionThe T cell engager (TCE), which redirects cytotoxic T cells to kill tumor cells, is emerging as a promising strategy to treat cancer patients, especially those with a low-mutation-burden tumor or a low number of…

1. IntroductionCancer, a leading cause of mortality globally, presents a complex challenge in medical science, particularly due to its ability to metastasize (spread) to distant organs. The key to understanding and combating this…

Meningiomas are graded by microscopic appearance, rate of growth and tendency to invade other tissues. Credit: National Cancer Institute…

Credit: Unsplash/CC0 Public Domain A pair of medications that make malignant cells act as if they have a virus could hold new promise for…

Schematic representation of the role of the LDHA–ERK–STAT3/YAP pathway in regulation of CCL2 and CCL7 in glioblastoma cells, which, in turn, promotes macrophage…

1. Introduction4-1BBL (CD137L) is as a costimulatory molecule required for appropriate T-cell expansion, inducing the effector and memory responses in CD8+ T cells, a mechanism required for the immune system to fight tumoral cells .…

1 Introduction A fundamental goal for the application of artificial intelligence (AI) in surgery has been automated surgical step recognition (SSR) from intraoperative video footage (Jin et al., 2018). Automated detection of the step…

Getting a biopsy is often an important first step for cancer diagnosis and treatment. But brain tumors present unique challenges: to perform a biopsy, a neurosurgeon will likely need to drill into the skull, and removing brain tissue can…

1. IntroductionAcidosis is a well-established feature of cancer, favoring its progression and metastatic spread. Tumor acidosis is an extracellular condition provoked by an increased production of acidic molecules and protons, and it…

Clear cell renal cell carcinoma (CCRCC), by far the most common renal cancer subtype, is an aggressive tumor variant, serving in recent years as a prolific test bench in cancer research. Many of the recent advances in our knowledge…

JPM, Vol. 14, Pages 194: Influence of Tumor Stroma on the Aggressiveness of Poorly Cohesive Gastric Carcinoma Journal of Personalized Medicine doi: 10.3390/jpm14020194 Authors: Giorgio Malpeli Federica Filippini Fabrizio Tedone…

Transarterial chemoembolization or TACE places chemotherapy and synthetic materials called embolic agents into a blood vessel feeding a cancerous tumor to cut off the tumor's blood supply and trap…

1. IntroductionAnkylosing spondylitis (AS), classified as a subtype of spondyloarthritis, is a chronic inflammatory disease primarily affecting the spine and sacroiliac joints . Nonsteroidal anti-inflammatory drugs (NSAIDs) are the…

High exposure to radiofrequency radiation (RFR) in rodents resulted in tumors in tissues surrounding nerves in the hearts of male rats, but not female rats or any mice, according to draft studies from the National Toxicology…

1. IntroductionWilms’ tumor, also known as nephroblastoma, is the most common childhood renal neoplasm. The history of Wilms’ tumor treatment is marked by the integration of surgery, radiation therapy, and chemotherapy, leading to…

1. IntroductionMinimally invasive breast biopsy or diagnostic needle biopsy is currently the standard of care for obtaining an initial tissue diagnosis of a breast abnormality. The emergence of this standard was driven in part by the…

1. IntroductionThe suppressor of cytokine signaling 1 (SOCS1) is an inhibitor of the JAK-STAT signaling pathway induced by cytokines and is an indispensable regulator of inflammatory responses induced by Toll-like receptor and IFNγ…

Introduction Lung cancer is the second most diagnosed cancer and the leading cause of cancer death in 2020. With an estimated 2.2 million new cancer cases and 1.8 million deaths in 2020, it represents approximately one in 10 (11.4%)…

1. IntroductionGastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) represent a heterogeneous group of rare neoplasms arising from neuroendocrine cells. GEP-NEN are classified into well-differentiated neuroendocrine neoplasm, i.e.,…

19ER neg 91% PR neg 81%HER2 neg 80.0%Axillary lymph node metastases n = 4-Squamous cell carcinoma n = 10-Mesenchymal differentiation with chondroid and mixed metaplasia n = 3-Spindle carcinoma n = 3-Low-grade adenosquamous carcinoma n =…

Brain and other central nervous system (CNS) cancers are the leading cause of childhood cancer deaths in the United States. This type of cancer is the second most common type of childhood cancer after leukemia. Physicians treating CNS…

Highly effective even in the low-oxygen environment of tumors Radiation kills tumors by creating oxygen free radicals that damage the tumor DNA. However, the lack of oxygen in the center of tumors blocks the production of free radicals,…

Single-cell variations can indicate if treatment is working, or time to change course Understanding the variability in individual cells of a tumor can be a valuable guide to the choice and course of treatment. NIBIB-funded researchers…

2. LymphocytesCompared to myeloid cells, lymphocytes are much less numerous in gliomas, with an estimated frequency of 1–5% of all cellular tumor components . However, in contrast to their low numbers, they have an outstanding…

A Stanford Medicine-led, international study of hundreds of samples from patients with Hodgkin lymphoma has shown that levels of tumor DNA circulating in their blood can identify who is responding well to treatment and others who…

1 IntroductionCancer is one of the highest causes of morbidity globally (1). Accumulation of genetic mutations brings about this disease; however, the progression would not have been possible by itself alone, but rather with the help of…