CFZ rescues polyQ toxicity in worms and developing zebrafish. (a) Scheme illustrating the pipeline followed to evaluate Htt-Q94 in developing zebrafish. (b)…
A droplet microfluidics-based system for high-throughput screening of syncytium formation. a, Co-culture of spike-expressing sender cells (mCherry+) and…
Scientists at Washington University School of Medicine in St. Louis have shown that treating mice with an antibody that blocks the interaction between APOE proteins…
Investigation of the effect of VHH Z70 nanobody on jR2R3 P301L-induced tau fibrillization in cells. Credit: Proceedings of the National Academy of Sciences (2024).…
1. IntroductionHuntington’s disease (HD) presents an enduring challenge within the landscape of neurodegenerative disorders . It is a hereditary disorder characterized by a relentless progression of motor dysfunction, cognitive…
1. Introduction Coronavirus disease 2019 (COVID-19) is initially characterized by flu-like symptoms, which can be associated with pneumonia and multi-organ damage. The final clinical outcome varies greatly. While some patients may only…
Coronary artery disease (CAD) and peripheral artery disease (PAD) are two clinical conditions that often coexist, sharing the atherosclerotic process as a common pathophysiological mechanism. Nearly 40% of patients diagnosed with CAD…
1. IntroductionDespite improved survival rates for coronary artery disease (CAD) in recent years, CAD overall prevalence remains a significant concern . With the growing number of older people, along with rising rates of diabetes and…
1. IntroductionThymic epithelial tumors (TETs) are the most common mediastinal neoplasms, presenting clinicopathological and molecular heterogeneity. The most recent WHO classification divides them into six major histological subtypes,…
Rabbit hemorrhagic disease virus 2 has spread to 5 continents and has been confirmed in 29 states within the U.S. in addition to two Canadian territories at the time of this publication . The disease is characterized by high mortality…
CHICAGO, IL, November 1, 2021 – During National Alzheimer’s Disease Awareness Month and National Family Caregivers Month in November, the Alzheimer’s Association is teaming up with the Ad Council to launch a new national communications…
A brain region critical for memory is smaller in older adults with fewer than 10 teeth than in those who have most of their teeth, suggesting that tooth loss may precede the development of dementia
1. IntroductionFoot-and-mouth disease (FMD) is a highly contagious viral disease that affects cloven-hoofed animals and poses a significant threat to the livestock industry worldwide. The causative agent, the FMD virus (FMDV), a member…
The cerebellum of a person affected by kuruLiberski PP (2013)
A genetic study in an extraordinarily remote community in Papua New Guinea has uncovered new insights into a brain disease spread by people eating their…
It has been suggested that blood donors be genetically tested to make sure they don’t have an inherited form of Alzheimer’s, but others think this is unnecessaryBSIP/UIG Via Getty Images
Could Alzheimer’s disease be…
Introduction
The literature is consistent: Parkinson's disease (PD) impairs spatial-temporal gait performance. People with PD show shorter step length, larger step width, slower step velocity, and longer step duration (Barbieri et al.,…
Dr. Chelisa Cardinez (pictured) says the discovery finally provides an explanation for why patients with psoriasis may go on to develop psoriatic arthritis, leaving…
IntroductionTrichoderma ear rot disease in maize was first described in 1973 (Shurtleff et al., 1973). The Compendium of Corn Diseases considers several fungi as “secondary invaders”, including Trichoderma spp., which often cause disease…
1 Introduction
Alzheimer’s Disease (AD), the most prevalent form of dementia among the elderly (Mckhann et al., 1984), entails irreversible neurodegeneration. Progressive decline in cognitive abilities and memory deterioration are…
SEATTLE--(BUSINESS WIRE)-- #AGBT2024--NanoString Technologies, Inc. (OTC: NSTGQ), a leading provider of life science tools for discovery and translational research, today announced that research using the company’s CosMx™ Spatial…
Detecting tuberculosis early could play a significant role in eradicating the world’s most deadly infectious disease. The World Health Organization says 1.5 million people die from this devastating disease each year.
People…
NEW YORK, NY, August 16, 2023 – The Ad Council, in partnership with the Alzheimer’s Association and creative agency Lopez Negrete Communications, launched new public service advertisements (PSAs) “Some Things Come with Age” in an effort…
Infectious Disease Reports, Vol. 16, Pages 298-316: Current Progress and Future Perspectives in Contact and Releasing-Type Antimicrobial Coatings of Orthopaedic Implants: A Systematic Review Analysis Emanated from In Vitro and In Vivo…
Multiple crises worsened by climate change threaten lives of 45 million childrenAs a prolonged heatwave and drought grip several countries in Eastern and Southern Africa, UNICEF is sounding the alarm on the dire situation faced by…
Alexandre Boulanger is better know for building self-balancing exoskeletons at Wandercraft. For his next trick the Paris-based robotics entrepreneur is fronting work on a far lighter kind of wearable: An arm-worn patch for…
1 Introduction
The number of people living with dementia was estimated to be 55 million in 2019 and is expected to increase to 139 million by 2050 (International, ASD, 2022). With an aging population, the economic burden and caregiver…
1. IntroductionIdiopathic nephrotic syndrome (INS) is the most common form of glomerulopathy among children, representing more than 90 percent of cases in children between 1 and 10 years of age. It is characterized by massive…
1. IntroductionTea is an important cash crop in traditional agriculture. The market demand for tea is vast. Global tea production is over USD 1.7 billion annually, while the world tea trade is valued at about USD 9.5 billion .…
Intermittent fasting has gained popularity in recent years as a dietary approach with potential health benefits. So you might have been surprised to see headlines last week suggesting the practice could increase a person’s risk of…
Brain Sciences, Vol. 14, Pages 305: The Effect of Upright Stance and Vision on a Cognitive Task in Elderly Subjects and Patients with Parkinson’s Disease
Brain Sciences doi: 10.3390/brainsci14040305
Authors:
Marta Mirando…
1. IntroductionHypertension and chronic kidney disease (CKD) are pathophysiological states that are intimately related, as hypertension can be both a cause and a consequence of CKD. The prevalence of hypertension is high among patients…
The cerebellum of a person affected by kuruLiberski PP (2013)
A genetic study in an extraordinarily remote community in Papua New Guinea has uncovered new insights into a brain disease spread by people eating their…
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Open AccessReview
by
Soisungwan SatarugSoisungwan Satarug
Prof. Soisungwan Satarug is an academic researcher from the Translational…
Data from two CDC reports today show COVID-19 vaccine boosters remain safe and continue to be highly effective against severe disease over time.
In the first study, CDC reviewed data from two of its vaccine safety monitoring systems,…
Every year, 10 million people fall ill with tuberculosis. Even though the disease is both preventable and curable, it kills 1.5 million people each year, making it the world’s deadliest infectious disease. Over 25% of these deaths…
The UN’s top aid official in the Occupied Palestinian Territory, Jamie McGoldrick, reached Kamal Adwan hospital in Beit Lahia on Thursday, where children with the most severe and life-threatening hunger are being treated at a new World…
LA JOLLA, Calif.--(BUSINESS WIRE)---- $EQ--Equillium, Inc. (Nasdaq: EQ), a clinical-stage biotechnology company focused on developing novel therapeutics to treat severe autoimmune and inflammatory disorders, today announced that it will…
1 Introduction
Parkinson’s disease is a neurodegenerative disease of central nervous system (CNS) that can cause loss of dopamine-producing neurons in the substantia nigra (Braak and Del Tredici, 2008). The disease is characterized by…
BILLERICA, Mass.--(BUSINESS WIRE)--Quanterix Corporation (NASDAQ: QTRX), a leading provider of ultra-sensitive research products and high-definition diagnostics, today announced a specific partnership path for laboratories interested in…
1 Introduction
In 195 countries worldwide, there has been a significant increase in the advanced-age population, mainly as a result of substantial population growth (Chang et al., 2019). By 2050, 20% of the global population will be…
1. IntroductionCardiovascular diseases (CVD) represent a major concern in preventive health. An estimated 17.9 million people died from CVDs in 2019, representing 32% of global deaths worldwide. Of these deaths, 85% were due to heart…
1 Introduction
Alzheimer’s disease (AD), typically embodied by dysmnesia, language deficits, cognitive bewilderment and behavioral anomalies, is a progressive neurodegenerative condition that unfolds gradually, worsening over time and…
1 Introduction
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by cognitive impairment, along with mental and behavioral abnormalities, and a decline in the ability to perform daily activities. It is the most…
1 Introduction
The diagnosis of Parkinson's disease (PD)relies on clinical assessments of cardinal motor symptoms such as bradykinesia, rigidity, tremor, and postural instability. Ocular movements in this patient population, however,…
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Submission received: 25 January 2024
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Revised: 9 March 2024
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Accepted: 14 March 2024
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Published: 19 March 2024
Abstract
Lumpy skin…