immune

Posted on April 25th, 2024 by Dr. Monica M. Bertagnolli In a study, an antibody…

The researchers wondered if they could tilt the balance back toward a younger immune system by depleting myeloid-leaning HSCs and allowing the more balanced HSCs to replace them. Their hunch was correct. Mice between 18 and 24…

1. IntroductionThymic epithelial tumors (TETs) are the most common mediastinal neoplasms, presenting clinicopathological and molecular heterogeneity. The most recent WHO classification divides them into six major histological subtypes,…

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Submission received: 18 January 2024 / Revised: 4 March 2024 / Accepted: 16 March 2024 / Published: 30 March 2024 Abstract PRRS is a…

Posted on March 28th, 2024 by Dr. Monica M. Bertagnolli When PD-1 receptors on T cells…

Credit: CC0 Public Domain Planes, trains, boats, automobiles and even feet. During the past decades and centuries, global travel and human…

Antibodies are proteins that can target and attack certain cellsMirrorImages/Alamy An experimental treatment rejuvenates the immune system of older mice, improving the animals’ ability to fight infections. If it…

1. IntroductionThe formation of distant metastases and the dissemination of cancer cells are thought to be the main causes of cancer-related mortality. The metastatic cascade typically initiates in the tumor-draining lymph nodes…

1. IntroductionDespite all the advances in the control of HIV-1 infection, the virus remains a major public health problem worldwide, with an estimated 1.3 million new infections each year . Because there is still no treatment available…

1. IntroductionVaccinations have transformed public health, notably since the 1960s, when national vaccination programs were established. According to World Health Organization data, vaccination programs prevent 2–3 million deaths each…

1. IntroductionCOVID-19 is attributed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which initially emerged in Wuhan, China, and quickly disseminated globally, leading to substantial economic and societal challenges .…

IntroductionIn beef production, the cost of feeding is a crucial factor that significantly impacts the overall cost of production. Studies have demonstrated that feed cost accounts for 60 to 70% of the total expenses in animal production…

1 Introduction Parkinson’s disease is a neurodegenerative disease of central nervous system (CNS) that can cause loss of dopamine-producing neurons in the substantia nigra (Braak and Del Tredici, 2008). The disease is characterized by…

Canada is seeing a resurgence of measles, with cases in the first quarter of 2024 already far surpassing the total for all of 2023. There were 12 cases last year, and more than three times that number so far in 2024, with 38…

1. Introduction4-1BBL (CD137L) is as a costimulatory molecule required for appropriate T-cell expansion, inducing the effector and memory responses in CD8+ T cells, a mechanism required for the immune system to fight tumoral cells .…

Figure 1. Design and characterization of four monovalent mRNA vaccines against high-pathogenic β-CoVs. (A) Skeleton diagram for the designation of the four LNP-mRNA vaccines. All four mRNAs contained the same 5’UTR, 3’UTR, poly A, and…

3.1. PeribunyaviridaeThe Peribunyaviridae family currently encompasses 7 genera and 219 virus species. Among these, the Orthobunyavirus genus, including the California (CSG), Simbu (SSG), and Bunyamwera serogroups, are the most…

1. IntroductionSince the beginning of the SARS-CoV-2 pandemic, several studies have emphasised a prolonged positivity of RT-PCR tests in the immunosuppressed population, which can be explained by the impairment of viral clearance by…

Maggi et al. (2010) Four patients with acute leukemiaBefore total body irradiation (TBI) and after allo-SCT (within the first 30 days; in 2 patients at days +50, +80, and +110 after transplantation)All patients (n = 4) developed plasma…

1. IntroductionInfluenza is a respiratory tract infection that affects the human health globally. Influenza is present seasonally and can cause pandemics. Influenza can give rise to a wide range of symptoms from asymptomatic to…

Viral infections can cause malignant diseases by utilizing elements of the viral genome, modulating normal cell cycle and repair mechanisms, constantly keeping the cells in an activated state, and disrupting the normal cell cycle…

1. IntroductionFour years have passed since the World Health Organization (WHO) declared the severe acute respiratory coronavirus-2 (SARS-CoV-2) outbreak a Public Health Emergency of International Concern on 31 January 2020 and a global…

Credit: CC0 Public Domain Insights into the workings of an immune cell surface receptor, called PD-1, reveal how treatments that restrict its action can potentially be strengthened to improve their…

Credit: CC0 Public Domain Insights into the workings of an immune cell surface receptor, called PD-1, reveal how treatments that restrict…

Four 2-weeks cycles with galunisertib lead to viral reactivation in blood. A Schematic representation of the study and sampling schedule. B Plasma VL in blood for…

How does your immune system decide between fighting invading pathogens now or preparing to fight them in the future? Turns out, it can change its mind. Every person has 10 million to 100 million unique T cells that have a critical…

A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms. STING is primarily on the lookout…

SEATTLE--(BUSINESS WIRE)--Alpine Immune Sciences, Inc. (NASDAQ: ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for autoimmune and inflammatory diseases, today announced the Company will…

1. IntroductionOlder age remains one of the most significant risk factors for many cancers. The median age at cancer diagnosis is 66 years, and the median age at cancer-related death is 72 years . More than nine out of 10 cancers are…

1. IntroductionHead and neck cancer (HNC) represents a significant cause of morbidity and mortality worldwide . Approximately 10% of patients with HNC present with metastatic disease at initial diagnosis, with an additional 40–60% of…

Women scientists have continued to excel in science, despite facing various challenges and barriers. In recent years, organizations and initiatives promoting gender equality and diversity in STEM fields have emerged to support and…

1 IntroductionAging is a complex process in which time-dependent progressive physiological changes result in impaired biological functions and decreased quality of life (López-Otín et al., 2013). The immune system is one of the major…

ROYAL OAK, Mich.--(BUSINESS WIRE)--Immunis.AI Announces Publication, in The Journal of Urology, of Results from Blood-Based Immune Profiling Study for Prostate Cancer Patients

One of the immune system’s primary roles is to detect and kill cells that have acquired cancerous mutations. However, some early-stage cancer cells manage to evade this surveillance and develop into more advanced…

One of the immune system’s primary roles is to detect and kill cells that have acquired cancerous mutations. However, some early-stage cancer cells manage to evade this surveillance and develop into more advanced…

The global vaccination campaign against SARS-CoV-2, the virus responsible for COVID-19, has been a monumental endeavor, marked by unprecedented collaboration between scientific researchers and pharmaceutical companies. One of the most…

Beyond the mode of childbirth, a significant determinant in shaping the infant’s gut microbiota is the feeding practice, as well as the introduction of solid foods into the child’s diet. The feeding method influences the abundance and…

1 Background Parkinson’s disease (PD) is a progressive neurodegenerative disorder primarily characterized by the progressive loss of dopaminergic neurons in the substantia nigra and abnormal α-synuclein aggregation in Lewy vesicles…

Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released. Author affiliations: University Medical…

ATHENS, Ga. & MEMPHIS, Tenn.--(BUSINESS WIRE)--CyanVac LLC, a clinical-stage intranasal vaccine company developing PIV5-vectored vaccines that harness the full breadth of the immune system to protect against serious infectious…

Credit: Neuron (2024). DOI: 10.1016/j.neuron.2024.01.013 A new Northwestern Medicine study has found the immune system in the blood of…

Credit: CC0 Public Domain Like other factors such as age, sex, and genetics, smoking has a major impact on immune responses. This is the…

1. IntroductionThe emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019 led to a global pandemic that has posed significant challenges to public health worldwide . Ongoing research is dedicated to…

1. IntroductionFoot-and-mouth disease (FMD) is caused by the foot-and-mouth disease virus (FMDV) and is highly contagious in cloven-hooved animal species, including cattle, pigs, goats, and other wild species . FMD is characterized by…

SEATTLE--(BUSINESS WIRE)--Alpine Immune Sciences, Inc. (NASDAQ: ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for autoimmune and inflammatory diseases, today announced that the Company…

By David Richards Welch poses for a quick photo during field work. (Photo courtesy of Barrett Welch) Prenatal exposure to arsenic may detrimentally impact early childhood immunologic development in Bangladesh, according to a…

The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/vaccines12020144/s1. Figure S1: Neutralization against Omicron sublineages BA.4/5, XBB.1.5, XBB.1.16, and EG.5.1 in individuals with or…

Media AdvisoryTuesday, January 30, 2024 NIH study finds distinct immune responses occur quickly when diets change, more research needed to determine health effects.What Researchers at the National Institutes of Health…

1. IntroductionPoliomyelitis, commonly known as polio, is an acute infectious disease caused by the poliovirus, which is classified into three serotypes: 1, 2, and 3. This disease predominantly affects humans, with children under the…

Graphical abstract. Credit: Immunity (2023). DOI: 10.1016/j.immuni.2023.12.001 Mice reach the twilight of their lives at around age two,…